发明公开
EP0218423A2 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use
失效
（9-取代硫基）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物，它们的制备和用途。
- 专利标题： 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use
- 专利标题（中）： （9-取代硫基）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物，它们的制备和用途。
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申请号： EP86307404.3申请日： 1986-09-25
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公开(公告)号： EP0218423A2公开(公告)日： 1987-04-15
- 发明人: Matsutani, Shigeru , Mizushima, Yukio , Doteuchi, Masami
- 申请人： SHIONOGI & CO., LTD.
- 申请人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka 541 JP
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka 541 JP
- 代理机构： Bizley, Richard Edward
- 优先权： JP213181/85 19850925; JP11591/86 19860121; JP181159/86 19860730
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/505
摘要：
9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula:
wherein n is 0 or 1, R is -COR 1 , -CONR 4 R 5 or -CH 2 R 6 , R 1 is C 1 -C 5 alkyl, C 3 -C 7 cycloalkyl, allylthio, styryl, phenoxymethyl, thienylmethyl, C 6 -C 10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R 2 and R 3 each is hydrogen, C l -C 5 alkyl, carboxy, C 2 -C 5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R 4 and R 5 each is hydrogen, C l -C 5 alkyl, C 3 -C 7 cycloalkyl or phenyl optionally substituted, and R 6 is pyridyl or phenyl optionally substituted are useful as antiulcer agents and may be provided by several routes.
wherein n is 0 or 1, R is -COR 1 , -CONR 4 R 5 or -CH 2 R 6 , R 1 is C 1 -C 5 alkyl, C 3 -C 7 cycloalkyl, allylthio, styryl, phenoxymethyl, thienylmethyl, C 6 -C 10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R 2 and R 3 each is hydrogen, C l -C 5 alkyl, carboxy, C 2 -C 5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R 4 and R 5 each is hydrogen, C l -C 5 alkyl, C 3 -C 7 cycloalkyl or phenyl optionally substituted, and R 6 is pyridyl or phenyl optionally substituted are useful as antiulcer agents and may be provided by several routes.
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