There are described compounds of formula I,
in which X represents a C2 to 8 alkylene chain optionally interrupted by a double bond or by S(O) n , wherein n is 0, 1 or 2;
Y represents O or NH,
l and m each independently represent 2, 3 or 4,
R₁₀ represents phenyl substituted by one or more substituents R₂₃, which may be the same or different; or R₁₀ represents pyridyl, a saturated carbocyclic group, alkyl C 1 to 6 or hydrogen,
R₁₅ represents hydrogen or together with R₂₃ forms a (CH₂) p chain, wherein p represents 0, 1 or 2;
R₂₀, R₂₁, R₂₂ and R₂₃, which may be the same or different, independently represent hydrogen, alkyl C 1 to 6, NHR₂₅, SH, NO₂, halogen, CF₃, SO₂R₃₀, CH₂OH or OH, wherein R₂₅, represents hydrogen, alkyl C 1 to 6, alkanoyl C 1 to 6 or SO₂ alkyl C 1 to 6, and R₃₀ represents alkyl C 1 to 6 or NH₂,
provided that when X represents an uninterrupted C4 alkylene chain, Y represents NH, m represents 2, l represents 2, R₁₀ represents phenyl, R₁₅ represents hydrogen, and R₂₁, R₂₂ and R₂₃ represent hydrogen, then R₂₀ does not represent hydrogen or 4-OH,
and pharmaceutically acceptable salts and solvates thereof.
There are also described processes for the preparation of the compounds of formula I and pharmaceutical compositions containing them. The compounds of the invention may be used in the treatment or prophylaxis of renal failure or cardiovascular disorders.