发明公开
EP0226029A1 Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of the same
失效
牛疱疹病毒-1的胸苷激酶缺失突变体，含有针对牛鼻气管炎和它们的制备和使用过程中的相同疫苗。
- 专利标题： Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of the same
- 专利标题（中）： 牛疱疹病毒-1的胸苷激酶缺失突变体，含有针对牛鼻气管炎和它们的制备和使用过程中的相同疫苗。
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申请号： EP86115455.7申请日： 1986-11-07
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公开(公告)号： EP0226029A1公开(公告)日： 1987-06-24
- 发明人: Kit, Malon , Kit, Saul
- 申请人： NOVAGENE, INC. , Baylor College of Medicine
- 申请人地址： P.O. Box 270275 Houston Texas 77277 US
- 专利权人： NOVAGENE, INC.,Baylor College of Medicine
- 当前专利权人： NOVAGENE, INC.,Baylor College of Medicine
- 当前专利权人地址： P.O. Box 270275 Houston Texas 77277 US
- 代理机构： Hansen, Bernd, Dr.rer.nat.
- 优先权： US796840 19851112
- 主分类号： A61K39/265
- IPC分类号： A61K39/265
摘要：
Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.
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