发明公开
EP0240256A2 Compounds useful in treating sickle cell anemia
失效
Verbindungen von Nutzen bei der Behandlung vom Herrickschen Syndrom。
- 专利标题： Compounds useful in treating sickle cell anemia
- 专利标题（中）： Verbindungen von Nutzen bei der Behandlung vom Herrickschen Syndrom。
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申请号： EP87302643.9申请日： 1987-03-26
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公开(公告)号： EP0240256A2公开(公告)日： 1987-10-07
- 发明人: Abraham, Donald J. , Cragoe, Edward J., Jr. , Woltersdorf, Otto W., Jr.
- 申请人： Merck & Co., Inc. , UNIVERSITY OF PITTSBURGH
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： Merck & Co., Inc.,UNIVERSITY OF PITTSBURGH
- 当前专利权人： Merck & Co., Inc.,UNIVERSITY OF PITTSBURGH
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US848078 19860404; US848195 19860404; US848080 19860404; US848079 19860404
- 主分类号： C07C59/90
- IPC分类号： C07C59/90 ; C07C62/38 ; C07C233/46 ; C07C235/32 ; C07C235/70 ; C07C205/27 ; C07C205/49
摘要：
The present invention is directea to compounds or the formula (I) useful as anti-sickling agents and to pharmaceutical compositions of these compounds wherein formula
V is selected from:
which R, is ethyl, propyl or isopropyl;
in which R 2 is H or lower alkyl;
in which
R 3 is lower alkyl;
W is selected from:
. A 2 is (CH 2 )n 2 -C(CH 3 ) 2 , -C(CH 2 ) 3 - and n 2 = 1 to 5; X is 0 or 1;
R3 is HO- or
A3 is -(CH 2 )n 3 or -C(CH 2 ) 3 - and
n 3 = 1 to 5;
m is 0 or 1;
and
Y is H, Cl or OCH 3 ;
Z is H or Cl;
provided that
(i) when W is
and Y and Z are Cl;
(ii) when W is
Y and Z are Cl, with the proviso that when R 2 is C 2 H 5 , R 2 is H and X is O, n 2 is 2 to 5;
(iii) When W is
with the proviso that when R3 is OH, Y is H or Cl and m is 1, n 3 = 4 or 5; (iv) when W is
and Y and Z are Cl.
V is selected from:
which R, is ethyl, propyl or isopropyl;
in which R 2 is H or lower alkyl;
in which
R 3 is lower alkyl;
W is selected from:
. A 2 is (CH 2 )n 2 -C(CH 3 ) 2 , -C(CH 2 ) 3 - and n 2 = 1 to 5; X is 0 or 1;
R3 is HO- or
A3 is -(CH 2 )n 3 or -C(CH 2 ) 3 - and
n 3 = 1 to 5;
m is 0 or 1;
and
Y is H, Cl or OCH 3 ;
Z is H or Cl;
provided that
(i) when W is
and Y and Z are Cl;
(ii) when W is
Y and Z are Cl, with the proviso that when R 2 is C 2 H 5 , R 2 is H and X is O, n 2 is 2 to 5;
(iii) When W is
with the proviso that when R3 is OH, Y is H or Cl and m is 1, n 3 = 4 or 5; (iv) when W is
and Y and Z are Cl.
公开/授权文献
- EP0240256B1 Compounds useful in treating sickle cell anemia 公开/授权日：1992-04-29
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