发明公开
- 专利标题： Naphthalene derivatives, process for their preparation and pharmaceutical compositions containing the same
- 专利标题（中）： 萘衍生物，其制备方法和含有该衍生物的药物组合物
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申请号： EP87109481.9申请日： 1987-07-01
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公开(公告)号： EP0251315A3公开(公告)日： 1989-06-07
- 发明人: Iwasaki, Tameo , Takashima, Kohki
- 申请人： TANABE SEIYAKU CO., LTD.
- 申请人地址： 2-10, Dosho-machi 3-chome Chuo-ku Osaka JP
- 专利权人： TANABE SEIYAKU CO., LTD.
- 当前专利权人： TANABE SEIYAKU CO., LTD.
- 当前专利权人地址： 2-10, Dosho-machi 3-chome Chuo-ku Osaka JP
- 代理机构： Hansen, Bernd, Dr.rer.nat.
- 优先权： JP155416/86 19860701
- 主分类号： C07C69/94
- IPC分类号： C07C69/94 ; C07C67/347 ; C07C67/08 ; A61K31/235 ; C07C235/42 ; C07D213/65 ; C07C323/00 ; C07C219/14 ; C07D265/30
摘要：
Naphthalene derivative of the formula:
wherein Ring A is a substituted or unsubstituted benzene ring; each of R¹ and R² is a group of the formula: -OR⁵, -NHR⁵ or
; or either one of R¹ and R² is a lower alkoxy group and other one is a group of the formula: -OR⁵, -NHR⁵ or
; each of R³ and R⁴ is a lower alkoxy group, or one of R³ and R⁴ is a lower alkoxy group and the other is a hydrogen atom; R⁵ is a substituted alkyl group, a heterocyclic group, a cycloalkyl group, an alkyl group of at least 5 carbon atoms or alkenyl group; and each of R⁶ and R⁷ is hydrogen atom or a lower alkyl group and salts thereof are disclosed.
Said naphthalene derivative (I) and its salts have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arteriosclerosis.
wherein Ring A is a substituted or unsubstituted benzene ring; each of R¹ and R² is a group of the formula: -OR⁵, -NHR⁵ or
; or either one of R¹ and R² is a lower alkoxy group and other one is a group of the formula: -OR⁵, -NHR⁵ or
; each of R³ and R⁴ is a lower alkoxy group, or one of R³ and R⁴ is a lower alkoxy group and the other is a hydrogen atom; R⁵ is a substituted alkyl group, a heterocyclic group, a cycloalkyl group, an alkyl group of at least 5 carbon atoms or alkenyl group; and each of R⁶ and R⁷ is hydrogen atom or a lower alkyl group and salts thereof are disclosed.
Said naphthalene derivative (I) and its salts have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arteriosclerosis.
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