发明公开
- 专利标题： Erythromycin a derivatives and method for the preparation of the same
- 专利标题（中）： 红霉素衍生物及其制备方法
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申请号： EP87311097.7申请日： 1987-12-16
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公开(公告)号： EP0272110A3公开(公告)日： 1989-10-25
- 发明人: Morimoto, Shigeo , Matsunaga, Tohru , Adachi, Takashi , Kashimura, Masato , Asaka, Toshifumi , Sota, Kaoru , Watanabe, Yoshiaki , Sekiuchi, Kazuto
- 申请人： TAISHO PHARMACEUTICAL CO. LTD
- 申请人地址： 24-1 Takata 3-chome Toshima-ku Tokyo 171 JP
- 专利权人： TAISHO PHARMACEUTICAL CO. LTD
- 当前专利权人： TAISHO PHARMACEUTICAL CO. LTD
- 当前专利权人地址： 24-1 Takata 3-chome Toshima-ku Tokyo 171 JP
- 代理机构： Paget, Hugh Charles Edward
- 优先权： JP300653/86 19861217
- 主分类号： C07H17/08
- IPC分类号： C07H17/08
摘要：
Erythromycin A derivativ es represented by the general formula
wherein R¹ is a group of the formula R⁷CH₂- (wherein R⁷ is a hydrogen group or a lower alkyl group) or a group of the formula R⁸O- (wherein R⁸ is a lower alkyl group), R² is R⁸, a cycloalkyl group, a phenyl group or an aralkyl group, or R² and R₇ together form an alkylene group, R³ is a hydrogen atom, a lower alkyl group, a phenyl group or an aralkyl group, or R³ and R⁷ together form an alkylene group, or R² and R³ together form an alkylene group, R⁴ is a lower alkyl group, R⁵ is a substituted silyl group, and R⁶ is a hydrogen atom or R₅, are useful as intermediates for the synthesis of antibacterial agents.
wherein R¹ is a group of the formula R⁷CH₂- (wherein R⁷ is a hydrogen group or a lower alkyl group) or a group of the formula R⁸O- (wherein R⁸ is a lower alkyl group), R² is R⁸, a cycloalkyl group, a phenyl group or an aralkyl group, or R² and R₇ together form an alkylene group, R³ is a hydrogen atom, a lower alkyl group, a phenyl group or an aralkyl group, or R³ and R⁷ together form an alkylene group, or R² and R³ together form an alkylene group, R⁴ is a lower alkyl group, R⁵ is a substituted silyl group, and R⁶ is a hydrogen atom or R₅, are useful as intermediates for the synthesis of antibacterial agents.
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