发明公开
EP0275305A4 DNA SEQUENCES CODING FOR MODIFIED FACTOR VIII:C AND MODIFIED FACTOR VIII:C-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THESE POLYPEPTIDES IN HIGH YIELDS.
失效
DNA序列替代修饰的因子VIII：C代码，所述修饰的因子VIII：C相关多肽AND METHOD FOR PRODUCING这些多肽大量。
- 专利标题： DNA SEQUENCES CODING FOR MODIFIED FACTOR VIII:C AND MODIFIED FACTOR VIII:C-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THESE POLYPEPTIDES IN HIGH YIELDS.
- 专利标题（中）： DNA序列替代修饰的因子VIII：C代码，所述修饰的因子VIII：C相关多肽AND METHOD FOR PRODUCING这些多肽大量。
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申请号： EP87905356申请日： 1987-07-31
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公开(公告)号： EP0275305A4公开(公告)日： 1988-11-07
- 发明人: BIOGEN N V
- 申请人： BIOGEN NV , PASEK MARK P
- 专利权人： BIOGEN NV,PASEK MARK P
- 当前专利权人： BIOGEN NV,PASEK MARK P
- 优先权： US89337586 1986-08-01
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K38/46 ; A61P7/02 ; A61P7/04 ; C07H21/04 ; C07K14/00 ; C07K14/745 ; C07K14/755 ; C12N15/00 ; C12N15/85 ; C12P21/02 ; C12R1/19
摘要：
DNA sequences coding on expression for modified factor VIII:C and modified factor VIII:C-like polypeptides and methods of making them in high yields in appropriate hosts transformed with those DNA sequences. DNA sequences containing internal deletions removing a major part of the sequence which codes on expression for the maturation polypeptide of factor VIII:C express modified factor VIII:C and modified factor VIII:C-like polypeptides 20 times more efficiently than DNA sequences coding for the factor VIII:C.
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