发明公开
EP0281261A3 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene
失效
吲哚，吲哚和Û二氢苯并呋喃和噻吩的3-氨基乙酸衍生物
- 专利标题： 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene
- 专利标题（中）： 吲哚，吲哚和Û二氢苯并呋喃和噻吩的3-氨基乙酸衍生物
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申请号： EP88301073.8申请日： 1988-02-09
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公开(公告)号： EP0281261A3公开(公告)日： 1989-11-23
- 发明人: Boegesoe, Klaus Peter , Perregaard, Jens Kristian
- 申请人： H. LUNDBECK A/S
- 申请人地址： Ottiliavej 7-9 DK-2500 Kobenhavn-Valby DK
- 专利权人： H. LUNDBECK A/S
- 当前专利权人： H. LUNDBECK A/S
- 当前专利权人地址： Ottiliavej 7-9 DK-2500 Kobenhavn-Valby DK
- 代理机构： Wilkinson, Stephen John
- 优先权： GB8704572 19870226
- 主分类号： C07C215/46
- IPC分类号： C07C215/46 ; C07C217/54 ; C07C219/26 ; C07C271/00 ; C07D307/81 ; C07D333/58 ; C07D209/14 ; A61K31/13 ; A61K31/22 ; A61K31/325 ; A61K31/34
摘要：
Indane-, dihydrobenzofurane-, dihydrobenzothiophene-, and indoline- derivatives of the following formula:
wherein X, R¹, R², R³ and R⁴ are as defined in Claim 1,
are effective at presynaptic DA receptors, or both at pre- and postsynaptic DA receptors, indicating usefulness in the treatment of disorders of the central nervous system (CNS) such as schizophrenia or Parkinson's disease. The 1-aminomethyl derivatives of Formula I exist as optical isomers, and the useful effects are often found in the single enantiomers to a different degree. A method for the preparation of compounds of Formula I is described.
wherein X, R¹, R², R³ and R⁴ are as defined in Claim 1,
are effective at presynaptic DA receptors, or both at pre- and postsynaptic DA receptors, indicating usefulness in the treatment of disorders of the central nervous system (CNS) such as schizophrenia or Parkinson's disease. The 1-aminomethyl derivatives of Formula I exist as optical isomers, and the useful effects are often found in the single enantiomers to a different degree. A method for the preparation of compounds of Formula I is described.
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