发明公开
- 专利标题： Fluorooxirane carboxylates
- 专利标题（中）： 氟烷基羧酸酯
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申请号： EP88301853.3申请日： 1988-03-03
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公开(公告)号： EP0283168A3公开(公告)日： 1989-06-14
- 发明人: Schiehser, Guy Alan , Strike, Donald Peter
- 申请人： AMERICAN HOME PRODUCTS CORPORATION
- 申请人地址： Five Giralda Farms Madison, New Jersey 07940-0874 US
- 专利权人： AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人： AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人地址： Five Giralda Farms Madison, New Jersey 07940-0874 US
- 代理机构： Brown, Keith John Symons
- 优先权： US26339 19870316; US34528 19870403; US88189 19870821
- 主分类号： C07D303/48
- IPC分类号： C07D303/48 ; A61K31/335
摘要：
There are disclosed compounds of the formula
wherein R¹ and R² are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro;
R³ is hydrogen, lower alkyl, or aryl or 7-12 carbon atoms;
A is -CH₂-, -O- or -S-;
m is 1 - 8;
n is 0 - 7, with the proviso that m + n ≦ 8;
or a pharmacologically acceptable salt thereof, and their use as fatty acid oxidation inhibitors possessing a significantly reduced potential for impairment of normal cardiac function, and having particular utility in the treatment of glucose and fatty acid metabolism disorders, such as diabetes.
wherein R¹ and R² are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro;
R³ is hydrogen, lower alkyl, or aryl or 7-12 carbon atoms;
A is -CH₂-, -O- or -S-;
m is 1 - 8;
n is 0 - 7, with the proviso that m + n ≦ 8;
or a pharmacologically acceptable salt thereof, and their use as fatty acid oxidation inhibitors possessing a significantly reduced potential for impairment of normal cardiac function, and having particular utility in the treatment of glucose and fatty acid metabolism disorders, such as diabetes.
公开/授权文献
- EP0283168A2 Fluorooxirane carboxylates 公开/授权日：1988-09-21
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