发明公开
EP0300688A1 Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
失效
吡咯衍生物，它们的制备方法和含有它们的药物组合物。
- 专利标题： Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
- 专利标题（中）： 吡咯衍生物，它们的制备方法和含有它们的药物组合物。
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申请号： EP88306464.4申请日： 1988-07-14
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公开(公告)号： EP0300688A1公开(公告)日： 1989-01-25
- 发明人: Dixon, John , Baxter, Andrew John Gilby , Manners, Carol Nancy , Teague, Simon
- 申请人： FISONS plc
- 申请人地址： Fison House Princes Street Ipswich Suffolk IP1 1QH GB
- 专利权人： FISONS plc
- 当前专利权人： FISONS plc
- 当前专利权人地址： Fison House Princes Street Ipswich Suffolk IP1 1QH GB
- 代理机构： Wright, Robert Gordon McRae
- 优先权： GB8717193 19870721; GB8730116 19871224
- 主分类号： C07D207/34
- IPC分类号： C07D207/34 ; C07D207/333 ; C07D403/06 ; C07D405/06 ; C07D409/06 ; A61K31/40 ; C07D207/00 ; C07D401/00 ; C07D405/00 ; C07D409/00
摘要：
Compounds of formula I,
wherein
R₁, R₂, R₃ and R₅ have the meanings defined in the specification,
G2 represents a chain -(CH₂) z (W) y -, in which W has various meanings including C=O, and up to two of the methylene segments in the chain (CH₂) z are optionally replaced by -NH- and one segment is optionally replaced by -O- or -(C=NR₄₀)-, and the chain is optionally unsaturated and optionally substituted, and
A is a 5- or 6-membered ring or a bicyclic or tricyclic fused ring system, A being optionally substituted by various substituents,
possess useful pharmacological properties, in particular as cardiotonics.
Also described are processes for the preparation of compounds of formula I, pharmaceutical compositions containing them and methods of treatment involving their use.
wherein
R₁, R₂, R₃ and R₅ have the meanings defined in the specification,
G2 represents a chain -(CH₂) z (W) y -, in which W has various meanings including C=O, and up to two of the methylene segments in the chain (CH₂) z are optionally replaced by -NH- and one segment is optionally replaced by -O- or -(C=NR₄₀)-, and the chain is optionally unsaturated and optionally substituted, and
A is a 5- or 6-membered ring or a bicyclic or tricyclic fused ring system, A being optionally substituted by various substituents,
possess useful pharmacological properties, in particular as cardiotonics.
Also described are processes for the preparation of compounds of formula I, pharmaceutical compositions containing them and methods of treatment involving their use.
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