发明公开
- 专利标题： Anthracycline Antibiotics
- 专利标题（中）： 蒽环类抗生素，Antibiotika。
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申请号： EP88116500.5申请日： 1988-10-05
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公开(公告)号： EP0311054A2公开(公告)日： 1989-04-12
- 发明人: Yoshimoto, Akihoro , Jodo Osamu Sanraku Hodogayaryo , Watanabe, Yoshio , Okamoto, Rokuro , Ishikura, Tomoyuki , Naganawa, Hiroshi , Sawa, Tsutomu , Takeuchi, Tomio
- 申请人： MERCIAN CORPORATION
- 申请人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo JP
- 专利权人： MERCIAN CORPORATION
- 当前专利权人： MERCIAN CORPORATION
- 当前专利权人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo JP
- 代理机构： Müller-Boré & Partner Patentanwälte
- 优先权： JP250712/87 19871006; JP211624/88 19880825
- 主分类号： C07H15/252
- IPC分类号： C07H15/252 ; A61K31/70
摘要：
Disclosed are anthracycline antibiotics of a formula (I):
in which R¹ and R² are hydroxyl groups, R³ is ethyl group, R⁴ is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or
R¹ and R² are hydroxyl groups, R³ is 1-hydroxyethyl group, R⁴ is hydrogen atom and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or
R¹, R² and R⁴ are hydroxyl groups, R³ is ethyl group and X represents daunosamine-rhodenose, daunosamine-deoxyfucose, rhodosamine-rhodenose, N-monomethyldaunosamine-rhodenose or N-monomethyldaunosamine-deoxyfucose; or
R¹ is methoxy group, R² is hydroxyl group, R³ is ethyl group, R⁴ is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or
R¹ and R⁴ are hydroxy groups, R² is hydrogen atom, R³ is ethyl group and X represents daunosamine-deoxyfucose, as well as pharmaceutically acceptable acid addition salts thereof. The antibiotics (I) have a carcinostatic activity and are useful as a carcinostatic.
in which R¹ and R² are hydroxyl groups, R³ is ethyl group, R⁴ is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or
R¹ and R² are hydroxyl groups, R³ is 1-hydroxyethyl group, R⁴ is hydrogen atom and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or
R¹, R² and R⁴ are hydroxyl groups, R³ is ethyl group and X represents daunosamine-rhodenose, daunosamine-deoxyfucose, rhodosamine-rhodenose, N-monomethyldaunosamine-rhodenose or N-monomethyldaunosamine-deoxyfucose; or
R¹ is methoxy group, R² is hydroxyl group, R³ is ethyl group, R⁴ is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or
R¹ and R⁴ are hydroxy groups, R² is hydrogen atom, R³ is ethyl group and X represents daunosamine-deoxyfucose, as well as pharmaceutically acceptable acid addition salts thereof. The antibiotics (I) have a carcinostatic activity and are useful as a carcinostatic.
公开/授权文献
- EP0311054B1 Anthracycline Antibiotics 公开/授权日：1994-08-31
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