A thienotriazolodiazepine compound represented by general formula (I), wherein Ar is phenyl, pyridyl, substituted phenyl or substituted pyridyl, R1 and R3 which may be the same or different are each hydrogen or alkyl having 1 to 4 carbon atoms, R2 is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl and R4 is straight-chain or branched alkyl alkenyl or alkinyl having 6 to 18 carbon atoms, or a thienodiazepine compound represented by general formula (II), wherein Ar, R1, R2, and R4 are as defined above, a pharmaceutically acceptable salt thereof, and a medicinal application thereof. These compounds are useful as a therapeutic agent for circulatory diseases and various diseases induced by a platelet activating factor. Further, the compound (II) is also useful as an intermediate for synthesis of the compound (I).