发明公开
EP0322182A2 Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
失效
氮杂双环化合物，其制备方法和含有它们的药物组合物。
- 专利标题： Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
- 专利标题（中）： 氮杂双环化合物，其制备方法和含有它们的药物组合物。
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申请号： EP88312038.8申请日： 1988-12-19
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公开(公告)号： EP0322182A2公开(公告)日： 1989-06-28
- 发明人: Orlek, Barry Sidney Beecham Pharmaceuticals , Wyman, Paul Adrian Beecham Pharmaceuticals , Wadsworth, Harry John Beecham Pharmaceuticals
- 申请人： BEECHAM GROUP PLC
- 申请人地址： Beecham House Great West Road Brentford Middlesex TW8 9BD GB
- 专利权人： BEECHAM GROUP PLC
- 当前专利权人： BEECHAM GROUP PLC
- 当前专利权人地址： Beecham House Great West Road Brentford Middlesex TW8 9BD GB
- 代理机构： Russell, Brian John
- 优先权： GB8729806 19871222; GB8812603 19880527; GB8824074 19881013
- 主分类号： C07D453/02
- IPC分类号： C07D453/02 ; C07D487/08 ; A61K31/435 ; A61K31/40
摘要：
Novel compounds of formula (I), processes for their preparation, and their use as pharmaceutical agents are described:
in which p represents an integer of 2 to 4; r represents an integer of 1 or 2; s represents 0 or 1; and X represents a group
in which A₁ is oxygen or sulphur, one of A₂ and A₃ is CR₁ and the other is nitrogen or CR₂, or A₂ is oxygen or sulphur, A₁ is CH and A₃ is CR₁, where R₁ and R₂ are independently selected from hydrogen and C₁₋₂ alkyl, with the proviso that when r is 2, R₁ and R₂ are hydrogen or methyl.
in which p represents an integer of 2 to 4; r represents an integer of 1 or 2; s represents 0 or 1; and X represents a group
in which A₁ is oxygen or sulphur, one of A₂ and A₃ is CR₁ and the other is nitrogen or CR₂, or A₂ is oxygen or sulphur, A₁ is CH and A₃ is CR₁, where R₁ and R₂ are independently selected from hydrogen and C₁₋₂ alkyl, with the proviso that when r is 2, R₁ and R₂ are hydrogen or methyl.
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