本发明涉及头孢菌素通式，其中m是0，1或2的衍生物，R 1是氢或酰基，R 2是氢，低级烷氧基，低级烷硫基或低级烷酰基，R 31表示氢，低级烷基，低级链烯基，C 3 -C 7 - 环烷基，卤 - 低级烷基或单 - ，二 - 或三 - 卤代苯基; žR 30 -C或氮，R 30表示氢或卤素，或R 30和R 31一起代表C 3 -C 5亚烷基，C 2 -C 4 - Alkylenmonooxygruppe或一个C 1 -C 2亚烷基二氧基，R 32是氢，卤素，低级烷基或任选取代的5- 或含6元杂环之一，显示出两个或三个氧，氮和/或硫原子和R 33表示氢或卤素或R 32和R 33一起表示C 1 -C 4亚烷基二氧基，和容易的可水解的酯和这些化合物的盐和水合物 式I化合物或其酯和盐。 本发明还涉及制备这些化合物的方法和相应的药物制剂。 该产品具有抗菌效果。

The invention relates to cephalosporin derivatives of general formula my where m is 0, 1 or 2, R¹ is hydrogen or an acyl group, R² is hydrogen, lower alkoxy, lower alkylthio or lower alkanoylamino, R³¹ substance water, lower alkyl, lower alkenyl, C₃-C₇- cycloalkyl, halo-lower alkyl or mono -, di- or tri-halophenyl; Z R³⁰ -C or nitrogen, R³⁰ represents hydrogen or halogen, or R³⁰ and R³¹ together represent a C₃-C₅ alkylene group, a C₂-C₄-Alkylenmono oxy group or a C₁-C₂ alkylenedioxy group, R³² is hydrogen, halogen, lower alkyl, or where appropriate substituted 5- or 6-membered hetero cyclic ring with one, two or three oxygen, nitrogen and / or sulfur atoms and R³³ hydrogen or halogen or R³² and R³³ together represent a C₁-C₄ alkylenedioxy group,
as well as readily hydrolyzable esters and salts of these compounds and hydrates of the Verbin compounds of formula I or of their esters and salts. The invention also relates to a process for preparing these compounds as well as corresponding pharmaceutical ceutical preparations. The products have antimicrobial activity.