发明公开
EP0331232A2 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
失效
5-脂氧合酶降解4-（4-苯基-1-哌嗪基）苯酚。
- 专利标题： 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
- 专利标题（中）： 5-脂氧合酶降解4-（4-苯基-1-哌嗪基）苯酚。
-
申请号： EP89200424.3申请日： 1989-02-21
-
公开(公告)号： EP0331232A2公开(公告)日： 1989-09-06
- 发明人: Van Wauwe, Jean Pierre Frans , Heeres, Jan , Backx, Leo Jacobus Jozef
- 申请人： JANSSEN PHARMACEUTICA N.V.
- 申请人地址： Turnhoutseweg 30 B-2340 Beerse BE
- 专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人地址： Turnhoutseweg 30 B-2340 Beerse BE
- 优先权： US161825 19880229
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; C07D295/04 ; C07D277/42 ; C07D277/18 ; C07D285/12 ; C07D233/36 ; C07D471/04 ; C07D249/12 ; C07D239/54 ; C07D257/04 ; C07D253/06
摘要：
5-Lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols having the formula
wherein R 1 and R 2 each independently are hydrogen, C 1-6 alkyl or halo; R 3 and R 4 each independently are hydrogen, halo, amino, nitro or trifluoromethyl; Y is a heterocyclic radical of formula
for use as a medicine. Compositions containing these compounds as active ingredient. Novel 4-(4-phenyhl-1-piperazinyl)phenols and methods for preparing these and the aforementioned compositions.
wherein R 1 and R 2 each independently are hydrogen, C 1-6 alkyl or halo; R 3 and R 4 each independently are hydrogen, halo, amino, nitro or trifluoromethyl; Y is a heterocyclic radical of formula
for use as a medicine. Compositions containing these compounds as active ingredient. Novel 4-(4-phenyhl-1-piperazinyl)phenols and methods for preparing these and the aforementioned compositions.
公开/授权文献
- EP0331232B1 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols 公开/授权日：1994-05-18
信息查询
