As new anthracycline derivatives are now produced 7-O-(2,6-dideoxy-2-fluoro-a-L-mannopyranosyl)-daunomycinone and -adriamycinone, their 4-demethoxy derivatives and 14-0-ester derivatives of the adriamycinone compounds of them, as well as 4-demethoxy-7-0-(2,6-dideoxy-2-fluoro-α-L-talopyranosyl)-daunomycinone and -adriamycinone and 14-0-ester derivatives of the adriamycinone compound thereof which )exhibit excellent antitumor activities and are useful as antitumor agents. These new anthracycline derivatives may be produced by various processes.