发明公开
- 专利标题： Naphthopyran derivatives and use thereof
- 专利标题（中）： 萘普生衍生物及其用途
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申请号： EP89106450.3申请日： 1989-04-12
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公开(公告)号： EP0337413A3公开(公告)日： 1990-11-22
- 发明人: Kanamaru, Tsuneo , Ishimaru, Takenori , Muroi, Masayuki
- 申请人： Takeda Chemical Industries, Ltd.
- 申请人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： JP94170/88 19880415
- 主分类号： C07D311/92
- IPC分类号： C07D311/92 ; A61K31/35
摘要：
The present invention relates to an aromatase inhibiting composition which contains a compound of the formula:
wherein R is hydroxy, lower alkoxy or amino which may be substituted by lower alkyl; R¹ is hydrogen or lower alkyl; and A is hydrogen, a group of the formula
in which R² is hydroxy, lower alkoxy or amino which may be substituted by lower alkyl and R³ is hydrogen or lower alkyl, or a group of the formula
in which R⁴ and R⁵ are independently hydrogen or lower alkyl, or a salt thereof. The present composition is useful in the prevention and treatment of estrogen-dependent diseases, such as breast cancer.
wherein R is hydroxy, lower alkoxy or amino which may be substituted by lower alkyl; R¹ is hydrogen or lower alkyl; and A is hydrogen, a group of the formula
in which R² is hydroxy, lower alkoxy or amino which may be substituted by lower alkyl and R³ is hydrogen or lower alkyl, or a group of the formula
in which R⁴ and R⁵ are independently hydrogen or lower alkyl, or a salt thereof. The present composition is useful in the prevention and treatment of estrogen-dependent diseases, such as breast cancer.
公开/授权文献
- EP0337413A2 Naphthopyran derivatives and use thereof 公开/授权日：1989-10-18
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