发明公开
- 专利标题： Atrial peptide derivatives
- 专利标题（中）： ATRIAL肽衍生物
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申请号： EP89108140.8申请日： 1989-05-05
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公开(公告)号： EP0341603A3公开(公告)日： 1990-07-04
- 发明人: Rockway, Todd W. , Kiso, Yoshiaki , Davidsen, Steven K. , Lucas, Scott D. , Thomas, A. Mitchell , Von Geldern, Thomas W.
- 申请人： ABBOTT LABORATORIES
- 申请人地址： One Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 专利权人： ABBOTT LABORATORIES
- 当前专利权人： ABBOTT LABORATORIES
- 当前专利权人地址： One Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US191644 19880509
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; A61K37/02
摘要：
Atrial peptides comprising the amino acid sequence as follows: wherein R₁ is hydrogen, Ser, Cit, SerSer, Arg, Carbamoyl Ser, Guanido-Ser-Ser, Amcca, Guanido-Amcca, Lys, ArgArg, Ser-Arg, Ser-Lys, Acetyl-Ser-Ser, D-Ser-Ser, Ser-D-Ser, Guanido-Aocta, Aunda, Aocta, Ahexa, HSer, Apenta, Papaa, Abuta, Mamba, Orn, D-Orn or Acetyl-apenta, Acetyl-Ahexa, Guanido;
R₂ is Cys, D-Cys or Pen;
R₃ is L-Phe, D-Ala, L-Ala, D-Val, D-Cha, Sar, D-Phg, Aib, β-Ala or Gly;
R₄ is Phe, Trp, D-Tic, L-Tic, N-MePhe, D-Ala, Tyr, 2-Thi, DimeDOPA or DOPA;
R₅ is Gly-Gly, Ala-Gly, D-Ala-Gly, Gly-Ala, Amcca, Mapaa or Papaa;
R₆ is Arg, D-Arg or Cit;
R₇ is Ile, Leu, D-Leu or Met;
R₈ is Asp, Asn, β-methylAsp, cycloAsp, Gly or Ser;
R₉ is Arg, D-Arg or Ala;
R₁₀ is Ile, Leu or Phe;
R₁₁ is Cys, D-Cys, HCys, Cys-4-thiomethylproline, or trans-4-thiomethylproline;
R₁₂ is absent, Phe, D-Ala-Phe, D-Phe, Cha, Pro, D-Pro, 2-Thi, Aic, D-Tic, trans-4-FPro, L-Tic, Leu, Ile or β-NAl;
R₁₃ is OH, Arg, Arg-NH₂, D-Arg, Gln, Lys, HomoArg, or Gly; or pharmaceutically acceptable salts, esters or amides thereof.
R₂ is Cys, D-Cys or Pen;
R₃ is L-Phe, D-Ala, L-Ala, D-Val, D-Cha, Sar, D-Phg, Aib, β-Ala or Gly;
R₄ is Phe, Trp, D-Tic, L-Tic, N-MePhe, D-Ala, Tyr, 2-Thi, DimeDOPA or DOPA;
R₅ is Gly-Gly, Ala-Gly, D-Ala-Gly, Gly-Ala, Amcca, Mapaa or Papaa;
R₆ is Arg, D-Arg or Cit;
R₇ is Ile, Leu, D-Leu or Met;
R₈ is Asp, Asn, β-methylAsp, cycloAsp, Gly or Ser;
R₉ is Arg, D-Arg or Ala;
R₁₀ is Ile, Leu or Phe;
R₁₁ is Cys, D-Cys, HCys, Cys-4-thiomethylproline, or trans-4-thiomethylproline;
R₁₂ is absent, Phe, D-Ala-Phe, D-Phe, Cha, Pro, D-Pro, 2-Thi, Aic, D-Tic, trans-4-FPro, L-Tic, Leu, Ile or β-NAl;
R₁₃ is OH, Arg, Arg-NH₂, D-Arg, Gln, Lys, HomoArg, or Gly; or pharmaceutically acceptable salts, esters or amides thereof.
公开/授权文献
- EP0341603A2 Atrial peptide derivatives 公开/授权日：1989-11-15
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