发明公开
EP0342665A3 Physiologically active substance tan-931, its derivatives, their production and use
失效
生理活性物质TAN-931，其衍生物及其生产和使用
- 专利标题： Physiologically active substance tan-931, its derivatives, their production and use
- 专利标题（中）： 生理活性物质TAN-931，其衍生物及其生产和使用
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申请号： EP89108926.0申请日： 1989-05-18
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公开(公告)号： EP0342665A3公开(公告)日： 1990-08-16
- 发明人: Kanamaru, Tsuneo , Hida, Tsuneaki , Muroi,, Masayuki
- 申请人： Takeda Chemical Industries, Ltd.
- 申请人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： JP124067/88 19880520
- 主分类号： C07C65/42
- IPC分类号： C07C65/42 ; A61K31/19 ; A61K31/235 ; C07D265/30
摘要：
A novel compound of the formula (I):
wherein R₁ is optionally esterified or amidated carboxyl; R₂, R₃ and R₄ are the same or different and are hydrogen or alkyl; A is fcrmyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R₁ is carboxyl, R₂, R₃ and R₄ are hydrogen and X is formyl are also disclosed.
wherein R₁ is optionally esterified or amidated carboxyl; R₂, R₃ and R₄ are the same or different and are hydrogen or alkyl; A is fcrmyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R₁ is carboxyl, R₂, R₃ and R₄ are hydrogen and X is formyl are also disclosed.
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