发明公开
EP0343961A3 Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity
失效
具有中枢神经系统活性的ARYL-和HETEROARYL PIPERAZINYL CARBOXAMIDID
- 专利标题： Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity
- 专利标题（中）： 具有中枢神经系统活性的ARYL-和HETEROARYL PIPERAZINYL CARBOXAMIDID
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申请号： EP89305255.5申请日： 1989-05-24
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公开(公告)号： EP0343961A3公开(公告)日： 1991-01-16
- 发明人: Abou-Gharbia, Magid Abdel-Megid , Yardley, John Patrick , Childers, Wayne Everett, Jr.
- 申请人： AMERICAN HOME PRODUCTS CORPORATION
- 申请人地址： Five Giralda Farms Madison, New Jersey 07940-0874 US
- 专利权人： AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人： AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人地址： Five Giralda Farms Madison, New Jersey 07940-0874 US
- 代理机构： Wileman, David Francis, Dr.
- 优先权： US197890 19880524; US297460 19890113
- 主分类号： C07D295/12
- IPC分类号： C07D295/12 ; A61K31/495 ; C07D239/42 ; A61K31/505 ; C07D407/12 ; C07D209/42 ; A61K31/40 ; C07D307/84 ; A61K31/34
摘要：
The invention discloses compounds of the formula (I)
wherein R¹ is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R² is unsubstituted or substituted phenyl, benzyl, pyridinyl, pyrimidinyl or pyrazinyl, wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R³ is H or lower alkyl of 1 to 3 carbon atoms, n is the integer 0 or 1; m is an integer from 2 to 5, and the pharmaceutically acceptable salts thereof which possess central nervous system activity.
wherein R¹ is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R² is unsubstituted or substituted phenyl, benzyl, pyridinyl, pyrimidinyl or pyrazinyl, wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R³ is H or lower alkyl of 1 to 3 carbon atoms, n is the integer 0 or 1; m is an integer from 2 to 5, and the pharmaceutically acceptable salts thereof which possess central nervous system activity.
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