发明公开
- 专利标题： New immunosuppressant-producing culture
- 专利标题（中）： 新的免疫力生产文化
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申请号： EP89202003.3申请日： 1989-07-31
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公开(公告)号： EP0353827A3公开(公告)日： 1991-01-30
- 发明人: Chen, Shieh-Shung T. , Inamine, Edward S. , Arison, Byron H. , Garrity, George M. , Mochales, Sagrario , Wicker, Linda S.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US229365 19880805
- 主分类号： C12N1/20
- IPC分类号： C12N1/20
摘要：
Described is a new microorganism, Actinoplanacete sp. , (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
公开/授权文献
- EP0353827A2 New immunosuppressant-producing culture 公开/授权日：1990-02-07
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