发明公开
EP0359540A2 Process for 1-carba(dethia) cephalosporins
失效
头孢西泮（dehia）Verfahren zur Herstellung von 1-Carba（dethia）头孢菌素。
- 专利标题： Process for 1-carba(dethia) cephalosporins
- 专利标题（中）： 头孢西泮（dehia）Verfahren zur Herstellung von 1-Carba（dethia）头孢菌素。
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申请号： EP89309281.7申请日： 1989-09-13
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公开(公告)号： EP0359540A2公开(公告)日： 1990-03-21
- 发明人: Blaszczak, Larry Chris
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Tapping, Kenneth George
- 优先权： US245185 19880916
- 主分类号： C07D463/00
- IPC分类号： C07D463/00 ; C07D501/14 ; C07D205/085
摘要：
The invention provides a free radical process for preparing 1-carba(1-dethia)cephalosporin antibiotics with 2-substituted methylcephalosporin 1,1-dioxides wherein the substituent on the 2-methylene group is a free radical precursor group such as a phenyl or alkylseleno group. The latter dioxides are treated with a free radical initiator, e.g., a trialkyltin hydride or actinic radiation at 40°C to 150°C to provide the 1-carba-3-cephem and 1-carba-2-cephem products. The invention also provides free radical compounds formed as intermediates in the process.
公开/授权文献
- EP0359540A3 Process for 1-carba(dethia) cephalosporins 公开/授权日：1991-09-04
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