发明公开
- 专利标题： Dispersable dihydroergotoxin tablets
- 专利标题（中）： 可分散的双氢麦角新碱片剂
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申请号： EP89117650.5申请日： 1989-09-25
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公开(公告)号： EP0361354A1公开(公告)日： 1990-04-04
- 发明人: Milovac, Jenny , Kovacic, Mateja , Kopitar, Zdravko , Urbancic-Smerkolj, Janja , Lenardic, Andrej , Zorz, Mirjan , Kofler, Bojan , Vene-Mozina, Angela , Nikolic, Vida , Lampret, Marija , Meden, Breda
- 申请人： LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
- 申请人地址： Verovskova 57 SI-61107 Ljubljana SI
- 专利权人： LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
- 当前专利权人： LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
- 当前专利权人地址： Verovskova 57 SI-61107 Ljubljana SI
- 代理机构： Müller-Boré & Partner Patentanwälte
- 优先权： YU1839/88 19880930
- 主分类号： A61K31/48
- IPC分类号： A61K31/48 ; A61K9/20
摘要：
There are described novel dispersible tablets of dihydroergotoxine or of acid addition salts thereof, containing 0.1 to 4 % by weight of dihydroergotoxine or its acid addition salts, 4 to 60 % by weight of one or more disintegrating agents, 0.8 to 10 % by weight of an organic acid and, optionally, 0.2 to 2 % by weight of an antioxidizing agent together with other common adjuvants.
The process for the manufacture of dispersible tablets of dihydroergotoxine and of acid addition salts thereof is carried out on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets.
Dispersible tablets disintegrate within less than 1 minute when brought in contact with water at room temperature to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particulary suitable for the aged. Dispersible tablets containing dihydroergotoxine or acid addition salts thereof excell by their improved rate of dissolution and good bioavailability.
The process for the manufacture of dispersible tablets of dihydroergotoxine and of acid addition salts thereof is carried out on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets.
Dispersible tablets disintegrate within less than 1 minute when brought in contact with water at room temperature to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particulary suitable for the aged. Dispersible tablets containing dihydroergotoxine or acid addition salts thereof excell by their improved rate of dissolution and good bioavailability.
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