发明公开
EP0366178A1 5-[N-methoxyethyl-N-methoxyethoxyethyl)aminomethyl]thieno [2,3-b] thiophene-2-sulfonamide as antiglaucoma agents
失效
噻吩并[2,3-b]噻吩-2-磺酰胺的N- [N-甲氧基乙基 - 正 - 甲氧基乙氧基乙基]氨基甲基酯。
- 专利标题： 5-[N-methoxyethyl-N-methoxyethoxyethyl)aminomethyl]thieno [2,3-b] thiophene-2-sulfonamide as antiglaucoma agents
- 专利标题（中）： 噻吩并[2,3-b]噻吩-2-磺酰胺的N- [N-甲氧基乙基 - 正 - 甲氧基乙氧基乙基]氨基甲基酯。
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申请号： EP89202589.1申请日： 1989-10-13
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公开(公告)号： EP0366178A1公开(公告)日： 1990-05-02
- 发明人: Hartman, George D. , Prugh, John D.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US260632 19881021
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/38
摘要：
This invention relates to novel aromatic sulfonamides useful in the treatment of elevated intraocular pressure. More particularly this invention relates to the compounds having the structural formula:
as well as the pharmaceutically and ophthalmologically acceptable salts thereof. This invention also relates to pharmaceutical compositions and the use thereof for systemic and ophthalmic use employing the novel compound of this invention as active ingredient for the treatment of elevated intraocular pressure, especially when accompanied by pathological damage such as in the disease known as glaucoma. The invention also relates to processes for preparation of the novel compound.
as well as the pharmaceutically and ophthalmologically acceptable salts thereof. This invention also relates to pharmaceutical compositions and the use thereof for systemic and ophthalmic use employing the novel compound of this invention as active ingredient for the treatment of elevated intraocular pressure, especially when accompanied by pathological damage such as in the disease known as glaucoma. The invention also relates to processes for preparation of the novel compound.
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