发明公开
- 专利标题： Novel antimicrobial fluoroquinolonyl cephems
- 专利标题（中）： 抗紫罗兰色素
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申请号： EP89870151.1申请日： 1989-10-20
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公开(公告)号： EP0366640A2公开(公告)日： 1990-05-02
- 发明人: Demuth, Thomas Prosser, Jr. , White, Ronald Eugene
- 申请人： Norwich-Eaton Pharmaceuticals, Inc.
- 申请人地址： 17 Eaton Avenue Norwich, New York 13815 US
- 专利权人： Norwich-Eaton Pharmaceuticals, Inc.
- 当前专利权人： Norwich-Eaton Pharmaceuticals, Inc.
- 当前专利权人地址： 17 Eaton Avenue Norwich, New York 13815 US
- 代理机构： Brooks, Maxim Courtney
- 优先权： US261949 19881024; US418025 19891012
- 主分类号： C07D501/26
- IPC分类号： C07D501/26 ; A61K31/545
摘要：
Antimicrobial fluoroquinolonyl cephems of the formula:
wherein
(1) R¹ and R² are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem;
(2) R³ is a substituted or unsubstituted, nitrogen-containing, heterocyclic moiety; and
(3) R⁴ is hydrogen, halogen, lower alkoxy or cyclic alkoxy, amino, nitro or cyano.
Preferably, R³ is substituted or unsubstituted piperazine, 3-aminopyrrolidine, or 3-aminomethylpyrrolidine. R⁴ is preferably hydrogen or halogen.
wherein
(1) R¹ and R² are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem;
(2) R³ is a substituted or unsubstituted, nitrogen-containing, heterocyclic moiety; and
(3) R⁴ is hydrogen, halogen, lower alkoxy or cyclic alkoxy, amino, nitro or cyano.
Preferably, R³ is substituted or unsubstituted piperazine, 3-aminopyrrolidine, or 3-aminomethylpyrrolidine. R⁴ is preferably hydrogen or halogen.
公开/授权文献
- EP0366640B1 Antimicrobial fluoroquinolonyl cephems 公开/授权日：1999-02-03
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