发明公开
EP0368409A2 Compositions for the transdermal delivery of buprenorphine salts
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Arzneizubereitungen zur transdermalen Verabreichung von Buprenorphinsalzen。
- 专利标题： Compositions for the transdermal delivery of buprenorphine salts
- 专利标题（中）： Arzneizubereitungen zur transdermalen Verabreichung von Buprenorphinsalzen。
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申请号： EP89202799.6申请日： 1989-11-07
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公开(公告)号： EP0368409A2公开(公告)日： 1990-05-16
- 发明人: Szuktak, Joan Bolduc , Manring, Gary Lee , Smith, Ronald Lee , Drust, Eugene George
- 申请人： Norwich Eaton Pharmaceuticals, Inc.
- 申请人地址： 17 Eaton Avenue Norwich New York 13815 US
- 专利权人： Norwich Eaton Pharmaceuticals, Inc.
- 当前专利权人： Norwich Eaton Pharmaceuticals, Inc.
- 当前专利权人地址： 17 Eaton Avenue Norwich New York 13815 US
- 代理机构： Suslic, Lydia
- 优先权： US269943 19881110
- 主分类号： A61K31/485
- IPC分类号： A61K31/485 ; A61K47/10 ; A61K47/12 ; A61K47/14
摘要：
Compositions for the transdermal delivery of buprenorphine salts comprising a safe and effective amount of a pharmaceutically-acceptable buprenorphine salt in a carrier comprising:
(a) a polar solvent material selected from the group consisting of C₃-C₄ diols, C₃-C₆ triols, and mixtures thereof; and
(b) a polar lipid material selected from the group consisting of fatty acids, fatty alcohols, fatty alcohol esters, fatty acid esters, and mixtures thereof;
wherein said polar solvent material and said polar lipid material are present in a weight ratio of solvent material:lipid material of from about 60:40 to about 99:1. Preferably, the polar solvent material is propylene glycol, and the polar lipid material is a C₁₂- C₁₈ fatty alcohol, a C₁₂-C₁₈ fatty acid, or an ester of a C₈-C₁₂ fatty alcohol or fatty acid. Particularly preferred polar lipid materials include oleic acid, lauryl alcohol, methyl laurate and methyl caprylate. The ratio of polar solvent material to polar lipld material is preferably from about 90:10 to about 98:2.
(a) a polar solvent material selected from the group consisting of C₃-C₄ diols, C₃-C₆ triols, and mixtures thereof; and
(b) a polar lipid material selected from the group consisting of fatty acids, fatty alcohols, fatty alcohol esters, fatty acid esters, and mixtures thereof;
wherein said polar solvent material and said polar lipid material are present in a weight ratio of solvent material:lipid material of from about 60:40 to about 99:1. Preferably, the polar solvent material is propylene glycol, and the polar lipid material is a C₁₂- C₁₈ fatty alcohol, a C₁₂-C₁₈ fatty acid, or an ester of a C₈-C₁₂ fatty alcohol or fatty acid. Particularly preferred polar lipid materials include oleic acid, lauryl alcohol, methyl laurate and methyl caprylate. The ratio of polar solvent material to polar lipld material is preferably from about 90:10 to about 98:2.
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