A trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compound of the formula:
wherein R¹ and R² are the same or different, and respectively represent hydrogen, C₁₋₁₀ alkyl, C₂₋₅ alkanoyl, formyl, C₁₋₄ alkoxy-carbonyl, amidino, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl­carbonyl, phenyl, phenylalkyl, benzoyl, naphthoyl, phenylalkoxy­carbonyl, benzylidene, pyridylcarbonyl, piperidyl, pyrroli­dylidene or piperidylidene which may be optionally substituted on the ring or R¹ and R² together with the adjacent nitrogen atom form 5 to 6-membered cycle which may have oxygen atom, sulfur atom or optionally substituted nitrogen atom in the cycle, or together with the adjacent nitrogen atom form phthalimido, R³ represents hydrogen or C₁₋₄ alkyl, R⁴ represents hydrogen or C₁₋₄ alkyl, R⁵ represents hydrogen, hydroxyl C₁₋₄ alkyl or phenylalkoxy. R⁶ represents hydrogen or C₁₋₄ alkyl, A represents single bond, C₁₋₅ straight chain alkylene, or alkylene which is substituted by C₁₋₄ alkyl, n represents 0 to 1, an optical isomer thereof and a pharmaceutically acceptable acid addition salt thereof.
These compounds possess antihypertensive activity, and coronary, cerebral and kidney circulation-improving activities and are useful as antihypertensive agents and agents for prevention and treatment of circulatory diseases.