Invention Publication
EP0381543A1 Use of solutions of atelocollagen and polyholosides, for example glycosaminoglycans, for the manufacture of microcapsules, microcapsules produced in this way, processes for the manufacture of such microcapsules and cosmetic, pharmaceutical or food compositions in which they are present
失效
端胶原和polyholosides，例如使用 用于微胶囊的制备溶液包含糖胺聚糖的，由此得到它们的制备微胶囊和方法; 含有营养物，药物或化妆品组合物制剂。
- Patent Title: Use of solutions of atelocollagen and polyholosides, for example glycosaminoglycans, for the manufacture of microcapsules, microcapsules produced in this way, processes for the manufacture of such microcapsules and cosmetic, pharmaceutical or food compositions in which they are present
- Patent Title (中): 端胶原和polyholosides，例如使用 用于微胶囊的制备溶液包含糖胺聚糖的，由此得到它们的制备微胶囊和方法; 含有营养物，药物或化妆品组合物制剂。
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Application No.: EP90400030.4Application Date: 1990-01-05
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Publication No.: EP0381543A1Publication Date: 1990-08-08
- Inventor: Levy, Marie-Christine , Andry, Marie-Christine , Huc, Alain , Buffevant, Chantal
- Applicant: COLETICA
- Applicant Address: 32, rue Saint Jean de Dieu 69007 Lyon FR
- Assignee: COLETICA
- Current Assignee: COLETICA
- Current Assignee Address: 32, rue Saint Jean de Dieu 69007 Lyon FR
- Agency: Portal, Gérard
- Priority: FR8901221 19890131; US336711 19890412
- Main IPC: B01J13/10
- IPC: B01J13/10 ; A61K7/00
Abstract:
The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules.
According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath.
These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. They are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.
According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath.
These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. They are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.
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