发明公开
- 专利标题： Hexitol derivatives
- 专利标题（中）： Hexitolderivate。
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申请号： EP90107245.4申请日： 1990-04-17
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公开(公告)号： EP0393574A2公开(公告)日： 1990-10-24
- 发明人: Suzuki, Fumio , Hayashi, Hiroaki , Kuroda, Takeshi , Kubo, Kazuhiro , Ikeda, Junichi
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100 JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100 JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP97032/89 19890417; JP293125/89 19891110
- 主分类号： C07D493/04
- IPC分类号： C07D493/04 ; C07D519/00 ; A61K31/34
摘要：
Disclosed are hexitol derivatives represented by the general formula (I):
wherein
Q represents a formula
wherein a represents NH, O or S,
each of b , c and d independently represents CH or N,
each of R¹, R², R³ and R⁴ independently represents hydrogen, lower alkyl, trifluoromethyl, aryl, lower alkanoyloxy, amino, lower alkylamino, lower alkanoylamino, lower alkanoyl, aroyl, halogen, nitro, (CH₂) m OR⁷, (CH₂) m SR⁷, (CH₂) m CO₂R⁷ where R⁷ represents hydrogen or lower alkyl and m represents an integer of 0 to 3,
each of R⁵ and R⁶ independently represents hydrogen or lower alkyl,
wherein each of Y¹ and Y² independently represents hydrogen, lower alkyl, hydroxyl, lower alkanoyloxy, nitrile or phenyl; or Y¹ and Y² are combined together to form oxygen,
each of Y³ and Y⁴ independently represents hydrogen or lower alkyl, and ℓ is an integer of 0 to 6, and where ℓ is an integer of 2 to 6, each
may be the same or different,
Z represents hydrogen or nitro, and, n is 2 or 3 or a pharmaceutically acceptable salt thereof. The compounds show prominent coronary vasodilative activities, and are useful in treating angina pectoris and myocardial infarction.
wherein
Q represents a formula
wherein a represents NH, O or S,
each of b , c and d independently represents CH or N,
each of R¹, R², R³ and R⁴ independently represents hydrogen, lower alkyl, trifluoromethyl, aryl, lower alkanoyloxy, amino, lower alkylamino, lower alkanoylamino, lower alkanoyl, aroyl, halogen, nitro, (CH₂) m OR⁷, (CH₂) m SR⁷, (CH₂) m CO₂R⁷ where R⁷ represents hydrogen or lower alkyl and m represents an integer of 0 to 3,
each of R⁵ and R⁶ independently represents hydrogen or lower alkyl,
wherein each of Y¹ and Y² independently represents hydrogen, lower alkyl, hydroxyl, lower alkanoyloxy, nitrile or phenyl; or Y¹ and Y² are combined together to form oxygen,
each of Y³ and Y⁴ independently represents hydrogen or lower alkyl, and ℓ is an integer of 0 to 6, and where ℓ is an integer of 2 to 6, each
may be the same or different,
Z represents hydrogen or nitro, and, n is 2 or 3 or a pharmaceutically acceptable salt thereof. The compounds show prominent coronary vasodilative activities, and are useful in treating angina pectoris and myocardial infarction.
公开/授权文献
- EP0393574B1 Hexitol derivatives 公开/授权日：1996-01-31
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