发明公开
- 专利标题： Avermectin derivatives
- 专利标题（中）： 阿维菌素衍生物
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申请号： EP90305980.6申请日： 1990-05-31
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公开(公告)号： EP0401029A1公开(公告)日： 1990-12-05
- 发明人: Mrozik, Helmut , Sinclair, Peter J.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US360620 19890602
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; A61K31/335 ; A01N43/90
摘要：
There are disclosed novel avermectin derivatives wherein the outer oleandrose ring of avermectin or avermectin monosaccharide is homologated by addition of diazomethane to 4˝- or 4′-oxo-avermectin to afford the oleandrose 4˝- or 4′-spiro-epoxide. The homologated avermectins can then be further derivatized to afford additional novel avermectins. The new compounds are potent antiparasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.
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