发明公开
- 专利标题: Biphenyl derivatives, process for preparing the same and intermediates therefor
- 专利标题(中): 联苯衍生物,其制备方法及其中间体
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申请号: EP90401483.4申请日: 1990-06-01
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公开(公告)号: EP0401125A3公开(公告)日: 1991-04-24
- 发明人: Iwasaki, Tameo , Kondo, Kazuhiko , Matsuoka, Yuzo , Matsumoto, Mamoru , Sugiura, Masaki
- 申请人: TANABE SEIYAKU CO., LTD.
- 申请人地址: 2-10, Dosho-machi 3-chome Chuo-ku Osaka JP
- 专利权人: TANABE SEIYAKU CO., LTD.
- 当前专利权人: TANABE SEIYAKU CO., LTD.
- 当前专利权人地址: 2-10, Dosho-machi 3-chome Chuo-ku Osaka JP
- 代理机构: Koch, Gustave
- 优先权: JP141988/89 19890602
- 主分类号: C07D317/68
- IPC分类号: C07D317/68 ; C07D413/04 ; A61K31/36
摘要:
Novel biphenyl derivatives of the formula:
wherein R¹ is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formula:
one or two of R² to R⁷ are hydrogen atom, and the remaining groups are the same or different and are each a lower alkoxy group, a phenyl(lower)alkoxy group or hydroxy group, or the adjacent two groups thereof combine to form a lower alkylenedioxy group, and Alk¹ is a lower alkylene group, or a pharmaceutically acceptable salt thereof, which are useful for the prophylaxis and treatment of hepatic diseases, and processes for preparing the same, and intermediates therefor.
wherein R¹ is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formula:
one or two of R² to R⁷ are hydrogen atom, and the remaining groups are the same or different and are each a lower alkoxy group, a phenyl(lower)alkoxy group or hydroxy group, or the adjacent two groups thereof combine to form a lower alkylenedioxy group, and Alk¹ is a lower alkylene group, or a pharmaceutically acceptable salt thereof, which are useful for the prophylaxis and treatment of hepatic diseases, and processes for preparing the same, and intermediates therefor.
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