A single-ended operational amplifier uses a plurality of chopper circuits (9, 16, 24) to alternately transpose matched transistor pairs for cancelling offset errors due to transistor mismatches from statistical process variations. The differential input signals are transposed while simultaneously transposing the currents in a current mirror (14, 15) and in the load devices (37). The matched devices comprising an output stage (36) remain untransposed since their contribution to offset error is minimal but their contribution to noise error would be substantial due to the potentially larger voltage differentials existing between them.