发明授权
EP0413763B1 METHOD FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES UTILIZING A GERMFREE ANIMAL
失效
方法生产单克隆抗体的使用胚芽,无动物成分的
- 专利标题: METHOD FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES UTILIZING A GERMFREE ANIMAL
- 专利标题(中): 方法生产单克隆抗体的使用胚芽,无动物成分的
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申请号: EP89906932.2申请日: 1989-06-12
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公开(公告)号: EP0413763B1公开(公告)日: 1996-11-06
- 发明人: GARGAN, Paul, E. , PLOPLIS, Victoria, A. , PLEASANTS, Julian, R.
- 申请人: AMERICAN BIOGENETIC SCIENCES, INC.
- 申请人地址: 1385 Akron Street Copiaque, NY 11726 US
- 专利权人: AMERICAN BIOGENETIC SCIENCES, INC.
- 当前专利权人: AMERICAN BIOGENETIC SCIENCES, INC.
- 当前专利权人地址: 1385 Akron Street Copiaque, NY 11726 US
- 代理机构: Hirsch, Marc-Roger
- 优先权: US206259 19880613
- 国际公布: WO8912690 19891228
- 主分类号: C12P21/00
- IPC分类号: C12P21/00 ; G01N33/566 ; C12Q1/64 ; A61K39/395 ; A61K51/00 ; A61K45/05 ; C07K16/00 ; C07K16/18
摘要:
The subject invention relates to a method for the production of monoclonal antibodies. The method utilizes an immunized germfree animal. The invention also provides a method for the use of such monoclonal antibodies, and polyclonal antibodies derived from an immunized germfree animal, for in vitro and in vivo clinical diagnostics and therapeutics. Also, the subject invention provides a fibrin-specific monoclonal antibody.
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