发明授权
- 专利标题： MACROCYCLIC CHELATES AND METHODS OF USE THEREOF
- 专利标题（中）： 大环螯合物，使用方法
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申请号： EP89907438.9申请日： 1989-05-24
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公开(公告)号： EP0416033B1公开(公告)日： 1996-03-06
- 发明人: GANSOW, Otto, A. , BRECHBIEL, Martin, W. , MAGERSTADT, Michael, A.
- 申请人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
- 申请人地址： National Technical Information Service, Office of Government Inventions and Patents, 5285 Port Royal Road Springfield, Virginia 22161 US
- 专利权人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
- 当前专利权人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
- 当前专利权人地址： National Technical Information Service, Office of Government Inventions and Patents, 5285 Port Royal Road Springfield, Virginia 22161 US
- 代理机构： Eyles, Christopher Thomas
- 优先权： US198538 19880525
- 国际公布： WO8911475 19891130
- 主分类号： C07D257/00
- IPC分类号： C07D257/00 ; C07F9/94 ; C07F7/24 ; C07F5/06 ; C07F3/08 ; C07F3/10 ; C07F5/00 ; C07F3/12 ; C07F3/00
摘要：
The invention is a chelate having general formula (I), wherein R1-4 is -CH2COOH; n is 1 to 5; X is a member selected from the group consisting of -NO2, -NH2, -NCS, -NHCOCH2-Z with Z being a member selected from the group consisting of Br and I, -COOH; -OCH2OOCH; and M is a metal ion being a member selected from the group of elements consisting of Bi, Pb, Y, Cd, Hg, Al, Th, Sr, and Lanthanides. The invention can include a chelate wherein M is a copper ion and n is an integer from 2 to 5. The invention includes chelate conjugates of general formula (I) and ligand conjugates of general formula (II). The invention also includes methods to use these compounds for treatment of cellular disorders and for diagnostic tests.
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