Invention Grant
EP0416069B1 NEUE LEUKOTRIEN-B 4 -DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
失效
新的六氟乙烯B 4衍生物，其制备方法及其作为药物使用
- Patent Title: NEUE LEUKOTRIEN-B 4 -DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
- Patent Title (English): New leucotriene b 4 derivatives, a method of preparing them, and their use as drugs
- Patent Title (中): 新的六氟乙烯B 4衍生物，其制备方法及其作为药物使用
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Application No.: EP90904600.5Application Date: 1990-03-16
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Publication No.: EP0416069B1Publication Date: 1993-07-28
- Inventor: HEINDL, Josef , SKUBALLA, Werner , BUCHMANN, Bernd , FRÖHLICH, Wolfgang , EKERDT, Roland
- Applicant: SCHERING AKTIENGESELLSCHAFT
- Applicant Address: 13342 Berlin DE
- Assignee: SCHERING AKTIENGESELLSCHAFT
- Current Assignee: SCHERING AKTIENGESELLSCHAFT
- Current Assignee Address: 13342 Berlin DE
- Priority: DE3909326 19890317
- International Announcement: WO9011272 19901004
- Main IPC: C07C69/736
- IPC: C07C69/736 ; C07C67/343 ; A61K31/215 ; C07C59/68 ; C07C43/23 ; C07C59/70 ; C07D207/16
Abstract:
The invention concerns leucotriene B4 derivatives of the formula (I) in which: n = 1-10, R1 is the CH2OH, COOR4, CONHR5 or CONR6R7 residue, A is a cis/trans or trans/trans -CH=CH-CH=CH- group or a tetramethylene group, B is an alkylene group with up to 10 C-atoms, D is a direct link, oxygen, sulphur, a -C=C- group or a -CH=CR8- group, B and D together form a direct link, R2 is a hydrogen atom or an acid residue of an organic acid with 1-15 C-atoms, R3 is a hydrogen atom, an alkyl residue (which may be substituted ) with 1-10 C-atoms, a cycloalkyl residue with 3-10 C-atoms, an aryl residue (which may be substituted ) with 6-10 C-atoms or a 5- or 6-membered heterocyclic residue plus, if R4 is a hydrogen atom, their salts with physiologically compatiblel bases and their cyclodextrinclathrates, as well as a method for their preparation and their pharmaceutical use.
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