发明公开
EP0420571A2 6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis
失效
6和/或7-取代基1,2,3,4,4a，9b-六氢-8-羟基 - 二苯并呋喃-3-烯烃抑制剂白细胞生成素。
- 专利标题： 6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis
- 专利标题（中）： 6和/或7-取代基1,2,3,4,4a，9b-六氢-8-羟基 - 二苯并呋喃-3-烯烃抑制剂白细胞生成素。
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申请号： EP90310478.4申请日： 1990-09-25
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公开(公告)号： EP0420571A2公开(公告)日： 1991-04-03
- 发明人: Rupprecht, Kathleen , Boger, Joshua S.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US411787 19890925
- 主分类号： C07D307/91
- IPC分类号： C07D307/91 ; C07D307/77 ; A61K31/34
摘要：
Positions 7-and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described.
These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.
These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.
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