发明公开
EP0428376A1 Method for preparation of taxol using an oxazinone
失效
Methode zur Herstellung von Taxol unter Verwendung von Oxazinon。
- 专利标题： Method for preparation of taxol using an oxazinone
- 专利标题（中）： Methode zur Herstellung von Taxol unter Verwendung von Oxazinon。
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申请号： EP90312366.9申请日： 1990-11-13
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公开(公告)号： EP0428376A1公开(公告)日： 1991-05-22
- 发明人: Holton, Robert A.
- 申请人： FLORIDA STATE UNIVERSITY
- 申请人地址： 2035 East Paul Dirac Drive Tallahassee, Florida US
- 专利权人： FLORIDA STATE UNIVERSITY
- 当前专利权人： FLORIDA STATE UNIVERSITY
- 当前专利权人地址： 2035 East Paul Dirac Drive Tallahassee, Florida US
- 代理机构： Eyles, Christopher Thomas
- 优先权： US436235 19891114; US603041 19901030
- 主分类号： C07D265/04
- IPC分类号： C07D265/04 ; C07D305/14
摘要：
Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula:
wherein R₁ is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR₇ wherein R₇ is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R₂ and R₅ are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR₈ wherein R₈ is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R₃ and R₆ are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and heteroaryl.
wherein R₁ is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR₇ wherein R₇ is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R₂ and R₅ are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR₈ wherein R₈ is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R₃ and R₆ are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and heteroaryl.
公开/授权文献
- EP0428376B1 Method for preparation of taxol using an oxazinone 公开/授权日：1996-01-10
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