发明公开
- 专利标题: Ester of L-carnitine with gamma-hydroxybutyric acid and pharmaceutical compositions containing it for inhibiting neuronal degeneration and for the treatment of coma
- 专利标题(中): L-肉碱与γ-羟丁酸和含有这些用于抑制神经元变性和彗差的治疗药物组合物的酯。
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申请号: EP90830465.2申请日: 1990-10-18
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公开(公告)号: EP0429403A2公开(公告)日: 1991-05-29
- 发明人: Tinti, Maria Ornella , Misiti, Domenico , Cavazza, Claudio
- 申请人: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 申请人地址: Viale Shakespeare, 47 I-00144 Roma IT
- 专利权人: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址: Viale Shakespeare, 47 I-00144 Roma IT
- 代理机构: Fassi, Aldo
- 优先权: IT4847589 19891020
- 主分类号: C07C229/22
- IPC分类号: C07C229/22 ; A61K31/22
摘要:
The L-carnitine ester with gamma-hydroxybutyric acid and its pharmacologically accceptable salts of formula (I)
wherein X⁻ is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.
wherein X⁻ is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.
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