发明公开
EP0439954A2 Hybrid molecules having translocation region and cell-binding region
失效
Hybridmolekülemit Translokations- und zellbindenden Regionen。
- 专利标题： Hybrid molecules having translocation region and cell-binding region
- 专利标题（中）： Hybridmolekülemit Translokations- und zellbindenden Regionen。
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申请号： EP90314221.4申请日： 1990-12-24
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公开(公告)号： EP0439954A2公开(公告)日： 1991-08-07
- 发明人: Murphy, John R.
- 申请人： SERAGEN, INC.
- 申请人地址： 97 South Street Hopkinton, MA 01748 US
- 专利权人： SERAGEN, INC.
- 当前专利权人： SERAGEN, INC.
- 当前专利权人地址： 97 South Street Hopkinton, MA 01748 US
- 代理机构： Deans, Michael John Percy
- 优先权： US456095 19891222; US538276 19900614
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; C12N15/26 ; C12N15/31 ; C12N15/48 ; C12N15/57 ; A61K48/00 ; C12N15/16
摘要：
A hybrid molecule including a first part, a second part and a third part connected by covalent bonds,
(a) the first part including a portion of the binding domain of a cell-binding ligand, which portion is able to cause the hybrid molecule of the invention to bind to an animal cell;
(b) the second part including a portion of a translocation domain of a protein, which portion is capable of translocating the third part across the cytoplasmic membrane of the cell; and
(c) the third part including a chemical entity to be introduced into the cell, provided that (i) the hybrid molecule is produced by expression of a recombinant DNA molecule encoding the hybrid molecule, and (ii) the second and third parts are not segments of the same naturally-occurring polypeptide toxin;
a recombinant DNA molecule encoding the hybrid molecule; and
a method of producing the hybrid molecule.
(a) the first part including a portion of the binding domain of a cell-binding ligand, which portion is able to cause the hybrid molecule of the invention to bind to an animal cell;
(b) the second part including a portion of a translocation domain of a protein, which portion is capable of translocating the third part across the cytoplasmic membrane of the cell; and
(c) the third part including a chemical entity to be introduced into the cell, provided that (i) the hybrid molecule is produced by expression of a recombinant DNA molecule encoding the hybrid molecule, and (ii) the second and third parts are not segments of the same naturally-occurring polypeptide toxin;
a recombinant DNA molecule encoding the hybrid molecule; and
a method of producing the hybrid molecule.
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