发明公开
EP0443862A1 Triamine derivatives and their acid-addition salts
失效
Triaminderivate和derenSäureadditionssalze。
- 专利标题： Triamine derivatives and their acid-addition salts
- 专利标题（中）： Triaminderivate和derenSäureadditionssalze。
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申请号： EP91301417.1申请日： 1991-02-22
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公开(公告)号： EP0443862A1公开(公告)日： 1991-08-28
- 发明人: Antoku, Fujio , Saji, Ikutaro , Ohashi, Naohito , Nagata, Ryu
- 申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
- 申请人地址： 2-8, Doshomachi 2-chome, Chuo-ku Osaka-shi Osaka-fu JP
- 专利权人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
- 当前专利权人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
- 当前专利权人地址： 2-8, Doshomachi 2-chome, Chuo-ku Osaka-shi Osaka-fu JP
- 代理机构： Cresswell, Thomas Anthony
- 优先权： JP43638/90 19900222
- 主分类号： C07C211/58
- IPC分类号： C07C211/58 ; C07C211/57 ; C07C217/84 ; C07C255/58 ; C07C237/10 ; C07C237/04 ; C07D215/40 ; C07D215/38 ; C07D239/42 ; C07D213/74 ; A61K31/135
摘要：
A triamine derivative of the formula (I)
wherein Ar¹ and Ar² are carbocyclic or heterocyclic single ring or fused ring aromatic groups, R¹, R² and R³ are hydrogen, lower alkyl, aryl aryl-alkyl, aryl-alkyloxycarbonyl, alkyloxycarbonyl or acyl, and A¹ a nd A² are lower alkylene groups optionally substituted by oxo, exhibits a high N-methyl-D-aspartic acid (NMDA) receptor antagonistic effect and are therefore useful as a medicine for nerve degeneration diseases.
wherein Ar¹ and Ar² are carbocyclic or heterocyclic single ring or fused ring aromatic groups, R¹, R² and R³ are hydrogen, lower alkyl, aryl aryl-alkyl, aryl-alkyloxycarbonyl, alkyloxycarbonyl or acyl, and A¹ a nd A² are lower alkylene groups optionally substituted by oxo, exhibits a high N-methyl-D-aspartic acid (NMDA) receptor antagonistic effect and are therefore useful as a medicine for nerve degeneration diseases.
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