发明公开
- 专利标题: Nitrogen-containing heterocyclic compounds, their production and use
- 专利标题(中): 含氮杂环化合物,其生产和使用
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申请号: EP91103497.3申请日: 1991-03-07
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公开(公告)号: EP0445811A3公开(公告)日: 1992-01-15
- 发明人: Morimoto, Akira , Nishikawa, Kohei
- 申请人: Takeda Chemical Industries, Ltd.
- 申请人地址: 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 代理机构: Lederer, Franz, Dr.
- 优先权: JP56205/90 19900307; JP56206/90 19900307; JP71051/90 19900320
- 主分类号: C07D213/80
- IPC分类号: C07D213/80 ; C07D401/10 ; C07D239/36 ; C07D403/10 ; A61K31/455
摘要:
Nitrogen-containing heterocyclic compounds of the formula (I):
wherein Y is N or CH; R 1 , which may be optionally bound through a hetero atom, is a hydrocarbon residue which may be substituted; R 2 and R 3 which may be same or different, are each independently hydrogen, cyano, nitro, optionally substituted lower alkyl, or -COD wherein D is alkoxy, hydroxy, halogen, or optionally substituted amino; or R 2 and R 3 are taken together to form a benzene ring which may be substituted; the dotted line is a chemical bond; Z is bound to a hetero nitrogen atom and is a group having the formula:
wherein R 4 is hydrogen, halogen or nitro, and R 5 is a residue capable of forming an anion or a residue convertible into an anion; A is a direct bond or a spacer having atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonist activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.
wherein Y is N or CH; R 1 , which may be optionally bound through a hetero atom, is a hydrocarbon residue which may be substituted; R 2 and R 3 which may be same or different, are each independently hydrogen, cyano, nitro, optionally substituted lower alkyl, or -COD wherein D is alkoxy, hydroxy, halogen, or optionally substituted amino; or R 2 and R 3 are taken together to form a benzene ring which may be substituted; the dotted line is a chemical bond; Z is bound to a hetero nitrogen atom and is a group having the formula:
wherein R 4 is hydrogen, halogen or nitro, and R 5 is a residue capable of forming an anion or a residue convertible into an anion; A is a direct bond or a spacer having atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonist activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.
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