发明公开
- 专利标题： 4-Piperidinyl-ergoline derivatives
- 专利标题（中）： 4-哌啶基 - 麦角灵衍生物
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申请号： EP91200446.2申请日： 1991-03-01
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公开(公告)号： EP0449346A3公开(公告)日： 1992-03-25
- 发明人: Mantegani, Sergio , Bandiera, Tiziano , Brambilla, Enzo , Buonamici, Metilde
- 申请人： PHARMACIA S.p.A.
- 申请人地址： Via Robert Koch, 1.2 I-20152 Milano IT
- 专利权人： PHARMACIA S.p.A.
- 当前专利权人： PHARMACIA S.p.A.
- 当前专利权人地址： Via Robert Koch, 1.2 I-20152 Milano IT
- 代理机构： Ferrario, Vittorino
- 优先权： GB9006772 19900327
- 主分类号： C07D457/02
- IPC分类号： C07D457/02 ; C07D457/00 ; A61K31/48
摘要：
A compound of the formula I
wherein R represents a hydrogen atom or a C₁ -C₄ alkyl group; R₁ represents a hydrogen, a halogen atom, a methyl group, a phenylthio group or an alkylthio group having from 1 to 4 carbon atoms; R₂ represents a hydrogen atom or a methoxy group; R₃ represents a hydrogen atom or R₂ and R₃ together represent a chemical bond; R₄ represents a hydrocarbon group having from 1 to 4 carbon atoms; R₅ represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a phenyl group and n is 0, 1 or 2 or a pharmaceutically acceptable salt thereof. Such compounds are useful as dopaminergic agents. A method of preparation and pharmaceutical compositions comprising them are also provided.
wherein R represents a hydrogen atom or a C₁ -C₄ alkyl group; R₁ represents a hydrogen, a halogen atom, a methyl group, a phenylthio group or an alkylthio group having from 1 to 4 carbon atoms; R₂ represents a hydrogen atom or a methoxy group; R₃ represents a hydrogen atom or R₂ and R₃ together represent a chemical bond; R₄ represents a hydrocarbon group having from 1 to 4 carbon atoms; R₅ represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a phenyl group and n is 0, 1 or 2 or a pharmaceutically acceptable salt thereof. Such compounds are useful as dopaminergic agents. A method of preparation and pharmaceutical compositions comprising them are also provided.
公开/授权文献
- EP0449346B1 4-Piperidinyl-ergoline derivatives 公开/授权日：1995-05-10
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