发明公开
EP0451626A3 The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids
失效
苯并噻吩类化合物在制备与激素氨基酸相关的中枢神经系统疾病的药物组合物中的应用
- 专利标题： The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids
- 专利标题（中）： 苯并噻吩类化合物在制备与激素氨基酸相关的中枢神经系统疾病的药物组合物中的应用
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申请号： EP91104888.2申请日： 1991-03-27
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公开(公告)号： EP0451626A3公开(公告)日： 1992-10-07
- 发明人: Jensen, Leif Helth , Drejer, Jorgen , Wätjen, Frank
- 申请人： NEUROSEARCH A/S
- 申请人地址： Smedeland 26 DK-2600 Glostrup DK
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： Smedeland 26 DK-2600 Glostrup DK
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US509284 19900413
- 主分类号： A61K31/55
- IPC分类号： A61K31/55
摘要：
The invention relates to the use of a benzodiazepine compound having the formula
wherein
R³ is hydrogen, C₁₋₈-alkyl which may be branched, or cycloalkylmethyl;
R⁷ and R⁸ are independently hydrogen, halogen, CF₃, CN, NO₂, NH₂, C₁₋₄-alkyl or C₁₋₄-alkoxy; and
R⁴ is hydrogen and R⁵ is hydrogen or C₁₋₇-alkyl; or R⁴ and R⁵ together signify (CH₂) n wherein n is an integer of 2-3, as the active ingredient for preparing a pharmaceutical composition for treating a central nervous system disorder related to the excitatory amino acids.
wherein
R³ is hydrogen, C₁₋₈-alkyl which may be branched, or cycloalkylmethyl;
R⁷ and R⁸ are independently hydrogen, halogen, CF₃, CN, NO₂, NH₂, C₁₋₄-alkyl or C₁₋₄-alkoxy; and
R⁴ is hydrogen and R⁵ is hydrogen or C₁₋₇-alkyl; or R⁴ and R⁵ together signify (CH₂) n wherein n is an integer of 2-3, as the active ingredient for preparing a pharmaceutical composition for treating a central nervous system disorder related to the excitatory amino acids.
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