发明公开
EP0457223A1 Stabilized fibroblast growth factor composition
失效
Stabilisierte Fibroblast-Wachstumsfaktor enthaltende Zusammensetzung。
- 专利标题： Stabilized fibroblast growth factor composition
- 专利标题（中）： Stabilisierte Fibroblast-Wachstumsfaktor enthaltende Zusammensetzung。
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申请号： EP91107682.6申请日： 1991-05-11
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公开(公告)号： EP0457223A1公开(公告)日： 1991-11-21
- 发明人: Folkman, Moses Judah , Shing, Yuen , Szabo, Sandor
- 申请人： CHILDREN'S MEDICAL CENTER CORPORATION , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 申请人地址： 55 Shattuck Street Boston Massachusetts 02115 US
- 专利权人： CHILDREN'S MEDICAL CENTER CORPORATION,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人： CHILDREN'S MEDICAL CENTER CORPORATION,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人地址： 55 Shattuck Street Boston Massachusetts 02115 US
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： US524144 19900515
- 主分类号： C07K15/00
- IPC分类号： C07K15/00 ; A61K37/02 ; A61K31/70
摘要：
Methods for stabilizing fibroblast growth factor (FGF) in heat, acid and/or proteolytic environments are provided. Such methods comprise combining or otherwise complexing FGF with a salt of sucrose octasulfate (SOS) and in particular with the aluminum (sucralfate) or potassium salts thereof. The present invention also provides FGF-stable compositions comprising SOS and FGF. Such compositions can be used in the treatment of FGF-responsive diseases including the treatment of wounds and ulcerative conditions of the gastrointestinal tract. The present invention also provides various diagnostic protocols employing SOS as well as diagnostic kits with SOS as a component thereof. Finally, the present invention provides methods of purifying FGF with SOS.
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