发明公开
- 专利标题： DC-89 derivatives as antitumoral agents
- 专利标题（中）： DC-89衍。
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申请号： EP91112235.6申请日： 1991-07-22
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公开(公告)号： EP0468400A1公开(公告)日： 1992-01-29
- 发明人: Saito, Hiromitsu , Nagamura, Satoru , Asai, Akira , Kobayashi, Eiji , Gomi, Katsushige
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 代理机构： Casalonga, Axel
- 优先权： JP198747/90 19900726
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D471/04 ; A61K31/44
摘要：
Novel DC-89 derivatives represented by general formula (I):
wherein X represents Cλ or Br; R 1 represents hydrogen, CONR 2 R 3 (in which R 2 and R 3 independently represent hydrogen, a straight-chain or branched alkyl group having 1 to 4 carbon atoms or phenyl group),
(in which n represents an integer of 4 to 7),
(in which R 4 represents oxygen, N-CH 3 or N-CH 2 CH 2 NH 2 ),
or SiR 5 R 6 R 7 (in which R 5 , R 6 and R 7 independently represent a straight-chain or branched alkyl group having 1 to 4 carbon atoms); and
or
(in which Y represents hydrogen or C0 2 CH 3 ); provided that when R 1 is hydrogen, CONR 2 R 3 or SiR 5 R 6 R 7 ,
and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity and are expected to be useful as anti-tumor compositions.
wherein X represents Cλ or Br; R 1 represents hydrogen, CONR 2 R 3 (in which R 2 and R 3 independently represent hydrogen, a straight-chain or branched alkyl group having 1 to 4 carbon atoms or phenyl group),
(in which n represents an integer of 4 to 7),
(in which R 4 represents oxygen, N-CH 3 or N-CH 2 CH 2 NH 2 ),
or SiR 5 R 6 R 7 (in which R 5 , R 6 and R 7 independently represent a straight-chain or branched alkyl group having 1 to 4 carbon atoms); and
or
(in which Y represents hydrogen or C0 2 CH 3 ); provided that when R 1 is hydrogen, CONR 2 R 3 or SiR 5 R 6 R 7 ,
and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity and are expected to be useful as anti-tumor compositions.
公开/授权文献
- EP0468400B1 DC-89 derivatives as antitumoral agents 公开/授权日：1996-08-14
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