发明公开
- 专利标题： Cyclic HIV principal neutralizing determinant peptides
- 专利标题（中）： 循环HIV主要中和决定因素
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申请号： EP91306582.7申请日： 1991-07-19
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公开(公告)号： EP0471453A3公开(公告)日： 1993-03-10
- 发明人: Sugg, Elizabeth E. , Dolan, Catherine A. , Bednarek, Maria A. , Tolman, Richard L. , Christensen, Burton G.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Barrett-Major, Julie Diane
- 优先权： US555112 19900719
- 主分类号： C07K7/52
- IPC分类号： C07K7/52 ; C07K7/54 ; C12P21/04 ; A61K37/02 ; A61K39/21
摘要：
Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides, or peptides immunologically equivalent therewith, having the structure :
wherein the ring system is formed by ring closure through a stable amide bond, are useful as analytical tools, as reagents in ELISA assays, or as reagents for making covalent conjugate immunogens. Conjugates containing these stable, cyclic peptides are useful for raising mammalian anti-peptide, anti-HIV, or HIV-neutralizing immune responses, and a composition containing such a conjugate may be used as a vaccine to prevent HIV-Disease, including Acquired Immune Deficiency Syndrome, (AIDS), or AIDS related complex, (ARC), or as an immunogen for treating humans afflicted with HIV-Diseases, such as AIDS or ARC.
wherein the ring system is formed by ring closure through a stable amide bond, are useful as analytical tools, as reagents in ELISA assays, or as reagents for making covalent conjugate immunogens. Conjugates containing these stable, cyclic peptides are useful for raising mammalian anti-peptide, anti-HIV, or HIV-neutralizing immune responses, and a composition containing such a conjugate may be used as a vaccine to prevent HIV-Disease, including Acquired Immune Deficiency Syndrome, (AIDS), or AIDS related complex, (ARC), or as an immunogen for treating humans afflicted with HIV-Diseases, such as AIDS or ARC.
公开/授权文献
- EP0471453A2 Cyclic HIV principal neutralizing determinant peptides 公开/授权日：1992-02-19
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