发明公开
- 专利标题： Pharmaceutical compositions containing therapeutically active organosilane derivatives and process for preparing same
- 专利标题（中）： 含有治疗性活性有机硅衍生物的药物组合物及其制备方法
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申请号： EP91306935.7申请日： 1991-07-29
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公开(公告)号： EP0472304A3公开(公告)日： 1992-04-22
- 发明人: Farkas, Sándor , Földeák, Sándor , Kárpáti, Egon , Hegyes, Péter , Kreidl, János , Szporny, László , Czibula, László , Vassné Petofi, Szilvia
- 申请人： Richter Gedeon Vegyészeti Gyár R.T.
- 申请人地址： Gyömröi ut 19-21 H-1475 Budapest X HU
- 专利权人： Richter Gedeon Vegyészeti Gyár R.T.
- 当前专利权人： Richter Gedeon Vegyészeti Gyár R.T.
- 当前专利权人地址： Gyömröi ut 19-21 H-1475 Budapest X HU
- 代理机构： Pett, Christopher Phineas
- 优先权： HU464690 19900727
- 主分类号： A61K31/695
- IPC分类号： A61K31/695
摘要：
The invention relates to pharmaceutical compositions containing an active ingredient at least one known organosilane derviative of formula (I),
wherein
R 1 represents a hydrogen or halogen atom ; A represents oxygen or =CH 2 or NR group, wherein R represents a hydrogen atom or a C 1-4 alkyl group ; m is 1, 2 or 3; and n is 1 or 2,
or a pharmaceutically acceptable salt thereof in admixture with one or more pharmaceutically acceptable carriers, excipients and/or diluents. The compositions of the invention possess muscle relaxant and antiparkinsonic effects, thus, they can be used for the treatment or prevention of diseases and conditions accompanied by hyperreflexia of the central nervous system and/or an increase of the muscular tone as well as nervous system injuries, degenerative nervous system disoders, sclerosis multiplex, myelopathies, rachicele, articular pains and Parkinson's disease in mammals including man.
wherein
R 1 represents a hydrogen or halogen atom ; A represents oxygen or =CH 2 or NR group, wherein R represents a hydrogen atom or a C 1-4 alkyl group ; m is 1, 2 or 3; and n is 1 or 2,
or a pharmaceutically acceptable salt thereof in admixture with one or more pharmaceutically acceptable carriers, excipients and/or diluents. The compositions of the invention possess muscle relaxant and antiparkinsonic effects, thus, they can be used for the treatment or prevention of diseases and conditions accompanied by hyperreflexia of the central nervous system and/or an increase of the muscular tone as well as nervous system injuries, degenerative nervous system disoders, sclerosis multiplex, myelopathies, rachicele, articular pains and Parkinson's disease in mammals including man.
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