发明公开
EP0474414A1 High purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val, process for preparing them and pharmaceutical compositions containing them
失效
肽精氨酸 - 赖氨酸 - 天冬氨酸和精氨酸 - 赖氨酸 - 天冬氨酸 - 缬氨酸的高纯度结晶的形式，它们的制备方法和含有它们的药物组合物。
- 专利标题： High purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val, process for preparing them and pharmaceutical compositions containing them
- 专利标题（中）： 肽精氨酸 - 赖氨酸 - 天冬氨酸和精氨酸 - 赖氨酸 - 天冬氨酸 - 缬氨酸的高纯度结晶的形式，它们的制备方法和含有它们的药物组合物。
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申请号： EP91307788.9申请日： 1991-08-23
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公开(公告)号： EP0474414A1公开(公告)日： 1992-03-11
- 发明人: Nyeki, Olga , Schon, Istvan Dr. , Denes, Laszlo,Dr. , Hajos, Gyö-rgy, Dr. , Szporny, Laszlo, Dr. , Ivanyi, Géza , Uberhardt, Tamàs , Kovacs, Lajos , Peter, Imre , Gazdag, Maria Dr. , Muck, Zsuzsanna née Kerepesi , Uberhardt, Ildiko née Faludi , Lorant, Gizella née Marek
- 申请人： Richter Gedeon Vegyészeti Gyár R.T.
- 申请人地址： Gyömröi ut 19-21 H-1475 Budapest X HU
- 专利权人： Richter Gedeon Vegyészeti Gyár R.T.
- 当前专利权人： Richter Gedeon Vegyészeti Gyár R.T.
- 当前专利权人地址： Gyömröi ut 19-21 H-1475 Budapest X HU
- 代理机构： Pett, Christopher Phineas
- 优先权： HU528490 19900823
- 主分类号： C07K1/00
- IPC分类号： C07K1/00 ; C07K5/08 ; C07K5/10 ; A61K38/04
摘要：
The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val.
The process is characterized in that
the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys-Asp-Val is allowed to stand at room temperature with 5 to 20 unit volume of an ethanolic solution containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml,
then the crystallized peptide is separated from the crystalline suspension, preferably after cooling.
Pharmaceutical compositions containing the crystalline forms of these peptides are also described.
The process is characterized in that
the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys-Asp-Val is allowed to stand at room temperature with 5 to 20 unit volume of an ethanolic solution containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml,
then the crystallized peptide is separated from the crystalline suspension, preferably after cooling.
Pharmaceutical compositions containing the crystalline forms of these peptides are also described.
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