发明公开
- 专利标题： KS-505 derivatives
- 专利标题（中）： KS-505衍。
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申请号： EP91114293.3申请日： 1991-08-26
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公开(公告)号： EP0480152A1公开(公告)日： 1992-04-15
- 发明人: Saito, Yutaka , Sano, Hiroshi , Nakanishi, Satoshi , Matsuda, Yuzuru , Kase, Hiroshi
- 申请人： KYOWA HAKKO KOGYO CO., LTD
- 申请人地址： 6-1, Ohtemachi Itchome Chiyoda-ku, Tokyo JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD
- 当前专利权人地址： 6-1, Ohtemachi Itchome Chiyoda-ku, Tokyo JP
- 代理机构： Casalonga, Axel
- 优先权： JP234173/90 19900904
- 主分类号： C07H15/26
- IPC分类号： C07H15/26 ; A61K31/71 ; C07D311/78 ; C07D493/04 ; A61K31/35 ; A61K31/365
摘要：
KS-505 derivatives of Formula (I) exhibit an inhibitory activity on cyclic nucleotide phosphodiesterase and are expected to be useful as pharmaceuticals.
wherein R 1 represents hydrogen or methyl; R 2 represents hydrogen or a compound of formula (II):
and X, Y and Z represent the following: when X is OCH 3 , Y and Z are combined together to form =O, and when Z is OCH 3 , X and Y are combined together to form -O-; provided that when R 1 is hydrogen, R 2 represents hydrogen, or a pharmaceutically acceptable salt thereof.
wherein R 1 represents hydrogen or methyl; R 2 represents hydrogen or a compound of formula (II):
and X, Y and Z represent the following: when X is OCH 3 , Y and Z are combined together to form =O, and when Z is OCH 3 , X and Y are combined together to form -O-; provided that when R 1 is hydrogen, R 2 represents hydrogen, or a pharmaceutically acceptable salt thereof.
公开/授权文献
- EP0480152B1 KS-505 derivatives 公开/授权日：1995-01-11
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