发明公开
- 专利标题： Hydroxylated inhibitors of HIV reverse transcriptase
- 专利标题（中）： 羟化酶抑制剂逆转转录酶von HIV。
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申请号： EP91309618.6申请日： 1991-10-17
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公开(公告)号： EP0481802A1公开(公告)日： 1992-04-22
- 发明人: Chen, Shieh-Shung Tom , Hsu, Annjia , Doss, George A. , Goldman, Mark E. , Balani, Suresh K. , Theoharides, Anthony D. , Hoffman, Jacob M., Jr. , Pitzenberger, Steven M. , Ramjit, Harri G. , Kauffman, Laura R. , Arison, Byron H. , Saari, Walfred S. , Rooney, Clarence S. , Wai, John S.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US599968 19901018; US712326 19910607; US769580 19911007
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; C07D413/06 ; C07D213/64 ; C07D213/70 ; C07D213/73 ; A61K31/44
摘要：
Novel biotransformed or synthetic hydroxy pyridinones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts (where appropriate), pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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